Endocrine Abstracts

Background: The effect of long term opioids on the hypothalamo-pituitary–adrenal (HPA) axis is conflicting. We present a case of a 21-year-old female who presented with adrenal insufficiency (AI) secondary to chronic tramadol use.Case summary: Our patient presented with a three year history of non-specific abdominal pain, lethargy and dizziness. No cause was found for these symptoms despite thorough investigations. One month before referral to Endoc...

Background: Low testosterone in men is associated with increase in all-cause and cardiovascular mortality. There is a high prevalence of hypogonadism in men with type 2 diabetes and testosterone replacement therapy (TRT) improves cardiovascular risk. However there is no published data regarding mortality in these patients in relation to testosterone levels, and the long term effect of TRT on mortality.Aim: We report a 6 year follow-up study examining the...

Hypogonadism is a common finding in men with metabolic syndrome (MS) and/or type 2 diabetes (T2D) which adversely affects quality of life, is associated with several cardiovascular (CV) risk factors and a greater risk of mortality. Testosterone replacement therapy (TRT) in pilot studies has beneficial effects on waist circumference (WC), insulin resistance, glycaemic control, lipid and inflammatory profiles.Testosterone replacement in hypogonadal metabol...

Introduction: Hypothyroidism in pregnancy may be associated with neurodevelopmental delay of the unborn baby. Timely management of abnormal thyroid function tests (TFTs) in pregnancy is important. In our centre, some patients attend an Endocrinology-led dedicated antenatal thyroid clinic, whilst others attend an Obstetrician-led general antenatal clinic.Objectives: The management of hypothyroid pregnant patients attending our centre was audited against T...

Background: In men with type 2 diabetes there is high prevalence of low levels of testosterone. There is accumulating evidence that low testosterone levels are associated with greater morbidity and mortality. There is no published data regarding mortality among men with type 2 diabetes in relation to testosterone levels.Aim: We report preliminary findings from our 4 to 7 years follow up study to examine the effect of baseline testosterone on all cause mo...

Introduction: Dopamine agonists have been routinely used in the treatment of prolactinomas since 1971. Increasingly, cabergoline is used as first-line treatment because of its tolerability and improved patient compliance. CSF rhinorrhoea is a rare but recognised adverse effect of rapid tumour shrinkage following dopamine agonist therapy. We report a case of cabergoline induced CSF rhinorrhoea in a young man with macroprolactinoma.Case: A 26-year-old stud...

Prader-Willi syndrome is characterized by severe hypotonia and feeding difficulties in early infancy, followed in later infancy or early childhood by excessive eating and gradual development of morbid obesity and learning difficulties. Hypogonadism occurs in both males and females, manifested by genital hypoplasia, incomplete pubertal development, and infertility. Type 2 diabetes mellitus is common in obese individuals, most likely secondary to hyperphagia. Diabetes is often d...

To determine the role of testosterone on liver fat deposition using the testicular feminised mouse (Tfm) model. The Tfm does not have a functional androgen receptor (AR) and low circulating levels of testosterone due to associated 17αhydroxylase deficiency.Liver tissue was obtained after 24 weeks of feeding with a cholesterol enriched diet from the following groups: (1) XY placebo-treated (littermate control), (2) Tfm placebo, (3) XY castrate placeb...

Introduction: Despite extensive research into IQ scores in congenital hypothyroidism (CH) during childhood there is little information on adult outcome in terms of pragmatic measures such as educational achievement, employment, residency and relationships.Patients and methods: We present the results of a questionnaire-based study examining these outcome measures in Scottish adults with permanent CH born between 1979 and 1991. The unaffected siblings of o...

After diabetes, thyroid disorder is the second most common endocrine disorder in women of reproductive age. Thyroid disorders in pregnancy have been proven to have adverse maternal and foetal outcome if not treated adequately and timely.Aim: The aim of this audit was to assess management and therapeutic interventions and outcomes of pregnancies complicated by thyroid disorders.Method: A retrospective case notes analysis of 35 pregn...